Table 2 Diagnostic criteria of acute FPIES (from reference [1], modified)
From: FPIES in exclusively breastfed infants: two case reports and review of the literature
| The diagnosis of acute FPIES requires the presence of vomiting (1–4 h after the ingestion of the suspected food) and the absence of classic IgE mediated allergic skin respiratory symptoms (major criteria), plus at least three of the following minor criteria: | |
| A second (or more) episode of repetitive vomiting after eating the same suspected food | |
| Extreme lethargy with any suspected reaction | |
| Marked pallor with any suspected reaction | |
| Need for Emergency Department visit with any suspected reaction | |
| Need for intravenous fluid support with any suspected reaction | |
| Hypotension | |
| Hypothermia | |
| If only a single FPIES reaction has occurred, it is strongly recommended to perform a diagnostic food challenge |