Probiotics’ efficacy in paediatric diseases: which is the evidence? A critical review on behalf of the Italian Society of Pediatrics

Table 3 Summary of the studies reporting the effects of different probiotics strains for the treatment of Irritable Bowel Syndrome and Functional Abdominal Pain-Not Otherwise

Author and year	Intervention	Control	Treatment duration	Follow up
Bauserman M et al. 2005 [107]	Lactobacillus GG 10¹⁰ bacteria twice per day	Placebo (inulin)	6 weeks	No follow up after treatment period
Francavilla R et al. 2010 [108]	Lactobacillus GG 3X10⁹ CFU twice per day	Placebo	8 weeks	8 weeks
Guandalini S et al. 2010 [109]	VSL#3 1 sachet once per day 4-11 years Twice per day 12–18 years	Placebo	6 weeks	6 weeks ^a
Giannetti e et al. 2017 [110]	Bifidobaacterium longum BB536 3 billions, Bifidobacterium infantis M-63 1 billion, Bifidobacterium breve M-16 V 1 billion	Placebo	6 weeks	6 weeks ^a
Gawrońska A et al. 2007 [112]	Lactobacillus GG 3X10⁹ twice per day	Placebo	4 weeks	No follow up after treatment period
Kianifar H et al 2015 [113]	Lactobacillus GG 1X10¹⁰ CFU/ml twice per day	Placebo	4 weeks	No follow up after treatment period

^a At the completion of the 6 weeks, no preparation was administered for 2 weeks. Then each patient was switched to the other group and followed for 6 weeks

ISSN: 1824-7288