Staphylococcal meningitis therapy with linezolid in a young infant: efficacy, CSF levels and side effects

Table 1 Plasma and CSF levels of linezolid at different time points

Linezolid concentration (μg/ml)^a
Time points	Plasma	CSF	CSF/Plasma ratio^b
1 h before the infusion	7.93	5.57	0.70
1 h after	48.44	4.91	0.10
6 h after	11.25	4.88	0.43

^aEffective range in infants: C_max 6.8–36.7 μg/ml (ref. [6])
^bCSF/Plasma ratio describing a good penetration into CSF: 0.7–0.8+/− 0.3 (ref. [9])

ISSN: 1824-7288